other treatment info

Potential side effects.

All medicines can have side effects, but not everybody gets them. If you have been taking a factor VIII replacement therapy for some time, you probably know the kinds of side effects to look out for. Studies with XYNTHA have shown that per infusion side effects do not occur very often. If they occurred, most reactions were mild or moderate. See list below.

Tell your doctor immediately if you are using increasing amounts of XYNTHA in order to control a bleeding episode.

During your treatment with XYNTHA, your blood will be checked for inhibitors to Factor VIII activity. Inhibitors are antibodies against Factor VIII, which are made by your immune system. The inhibitors stop the Factor VIII from working as well as it used to.

Tell your doctor as soon as possible if you do not feel well while you are using XYNTHA.

Injection of any medicine intravenously may have side effects. Often they are not serious but sometimes they can be. You may need medical treatment if you experience some side effects.

Tell your doctor if you notice any of the following and they worry you:

Stomach or bowel problems such as:
  • nausea
  • vomiting
  • loss of appetite
  • stomach pain or cramps
  • diarrhoea
Difficulty thinking or working because of:
  • headache
  • dizziness
  • drowsiness
  • numbness
  • muscle weakness or pain
  • joint pain
  • excessive sweating
  • flushing
  • fever
  • feeling faint
  • chest pain
  • rapid or irregular heartbeat
  • chills or feeling cold
Breathing problems such as:
  • shortness of breath
  • coughing
Changes in your sight, taste or touch such as:
  • blurred vision
  • altered taste
Skin problems such as:
  • itching
  • rash
  • bruising or bleeding
  • swelling of vein from a blood clot
Other problems such as:
  • difficulties in catheter access to a vein
  • injection site reaction, including pain and swelling

These are all uncommon to very rare side effects of Xyntha injection.

What to look out for

There are a few important things you need to keep in mind whenever you use Xyntha.

Stop using Xyntha immediately and contact your doctor or seek emergency care if you develop any allergic signs such as:

  • A swollen face, lips or tongue
  • Difficulty breathing
  • Shortness of breath
  • Chest tightness
  • Wheezing
  • Dizziness
  • Faintness
  • Rapid heart beat
  • Hives
  • A skin rash

Contact your doctor or nurse at your Haemophilia Treatment Centre immediately if your bleeding isn’t controlled with your usual dose or you are concerned about any side effects (including any not listed here).

Don’t be alarmed by this list of possible side effects as you may not experience any of them.



With a bit of extra forward planning you can travel with peace of mind about your treatment.

Tell your Haemophilia Treatment Centre about your trip well in advance.

Tell your tour operator or travel agent about your haemophilia and any special requirements when you book.

Make sure you have enough XYNTHA and equipment for your travels (for long trips, it may be possible to have XYNTHA delivered to you by Pfizer, depending on where you are).

Pack your XYNTHA and equipment in a separate case allowing easy access for inspections or infusion (keep it with you so it doesn’t get lost, broken or affected by temperature variations in the aircraft hold).

In fact, you can get a special Pfizer Travel Pack to keep all of your medication in when you’re travelling. If you’d like one just ask your Haemophilia Treatment Centre.

When travelling overseas, you must also remember to obtain a letter from your Haemophilia Treatment Centre to assist clearance of your medical supplies through customs.

And lastly, if you receive a regular XYNTHA delivery, remember to cancel it when you are away.