how to use xyntha?
Select your Guide
DUAL CHAMBER RECONSTITUTION GUIDE
MULTI-DOSE RECONSTITUTION GUIDE
A. Screw the plunger rod firmly into prefilled dual chamber syringe by pushing and turning firmly until resistance is felt.
Avoid contact with shaft of the plunger rod.
A. Remove the white tamper-evident seal by bending the seal to expose the rubber tip cap.
B. Remove the grey rubber tip cap and replace it with the protective blue-vented sterile cap (prevents pressure build up).
A. Gently advance plunger rod until the 2 stoppers inside meet and all the diluent is transferred to the chamber containing the XYNTHA powder.
C. Slowly advance the plunger rod until most, if not all, of the air is removed from the drug product chamber.
Please note: the solution should be clear to slightly opalescent and colourless. If it is not, the solution should be discarded and a new kit should be used.
B. Swirl gently several times until powder is dissolved.
Combining multiple XYNTHA® dual chamber syringes
The instructions below are for the use of multiple XYNTHA dual chamber syringes with a 10mL or larger luer lock syringe.
Reconstitute each XYNTHA dual chamber syringe according to instructions included with each kit.
Remove the green syringe connector from its package and the protective blue vented cap from its package.
Connect a 10mL or larger luer lock syringe to one end of the green syringe connector and the XYNTHA dual chamber syringe to the opposite end of the green syringe connector.
With the XYNTHA dual chamber syringe on top, slowly push the plunger rod until the contents empty into the 10mL or larger luer lock syringe.
Remove empty XYNTHA dual chamber syringe and attach any additional XYNTHA dual chamber reconstituted syringes to the green syringe connector in order to empty contents into the 10mL or larger luer lock syringe.
Remove the green syringe connector and attach the 10mL or larger luer lock syringe to the infusion set included inside the XYNTHA dual chamber syringe kit.
For further information about your treatment or
condition, see your healthcare professional.
- 250 IU
- 500 IU
- 1000 IU
- 2000 IU
- 3000 IU
The reconstituted solution should be used as soon as possible after dissolving the powder. If storage after reconstitution is necessary you should store the syringe with the protective blue-vented cap in an upright position, at 2 - 8°C and use within 3 hours. Only use solutions that are clear and colourless. Use only the accessories provided in the box for reconstitution and administration.
how to administer
XYNTHA dual chamber should be administered using the infusion set in your kit. You can use the syringe provided or, if more than one vial is needed, a large sterile disposable plastic luer lock syringe may be available from your Haemophilia Treatment Centre.
1. Attach the syringe to the luer end of the infusion set.
2. Apply a tourniquet and prepare the injection site by wiping the skin well with an alcohol swab provided in the kit.
3. Insert the needle on the infusion set tubing into the vein and remove the tourniquet.
4. The reconstituted XYNTHA should be injected intravenously over several minutes. The rate of administration should be determined by your comfort level.
5. After completion of XYNTHA treatment remove the infusion set and discard appropriately.
Contact your doctor or nurse if you have any questions on how to administer.